Dr. Crispino's laboratory studies the biology of normal and malignant hematopoiesis with an emphasis on the factors that drive progression of benign disorders to acute leukemia. Research in the lab ranges from the basic science of transcription to translational research aimed at developing treatments for blood disorders. A current major focus of the lab is to understand the increased risk of leukemia in children with Down syndrome and the role of GATA1 mutations and DYRK1A in oncogenesis. Another area of intense study is defining the mechanisms by which myeloproliferative disorders and myelodysplastic syndrome progress to acute myeloid leukemia. Finally, there is a major effort to understand the role of GATA1 in erythropoiesis. We seek an ambitious, motivated, and friendly postdoctoral scientist who has the desire to help advance our understand of blood disorders and improve the lives of patients.

Dr. Crispino has led a highly productive and well-funded laboratory, which is supported by an NCI R35 Outstanding Investigator Award, for more than 20 years. Recent publications include ones inthe Journal of Clinical Investigation,Cancer Discovery, andBlood. He is well known for his work on the increased incidence of leukemia in children with Down syndrome, on the contributions of GATA1 to red cell and megakaryocyte development, and on the role of megakaryocytes in myelofibrosis. He has mentored over 30 post-docs, clinical fellow, and PhD students, many of whom have moved to independent academic positions. He relocated his laboratory from Northwestern University in Chicago to St. Jude Children's Research Hospital in the summer of 2020. He is excited to be part of the outstanding scientific environment at St. Jude and to train the next generation of hematology researchers.

Candidates should have recently earned/expect to earn a Ph.D. and have published at least one first author primary research paper in a high impact peer reviewed journal. They should have experience in tissue culture and molecular biology. Experience with flow cytometry and animal models is a plus.

Diversity, Equity and Inclusion

St. Jude Children's Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world-regardless of race, religion or a family's ability to pay. Learn more about our history and commitment.

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital's roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

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